Effects of sulpiride on persistent neuroleptic-induced dyskinesia in monkeys.

Abstract

Five Cebus apella monkeys with persistent neuroleptic-induced dyskinesia were given a single dose of sulpiride (20 mg/kg i.m.). The dyskinesia was reduced in all five although four developed attacks of acute dystonia which had to be reversed by anticholinergic medication in three animals. In one monkey the administration of classic neuroleptics had earlier been shown to induce a typical sequence of events. First there was a similar reduction of dyskinesia as seen in the other monkeys, 1-2 days later there was noticed a rebound deterioration lasting for several days. Metoclopramide 0.5 mg/kg, caused such a rebound effect (for 2 days), whereas sulpiride did not.

• Authors: J E Häggström
• Journal: Acta psychiatrica Scandinavica. Supplementum (Acta Psychiatr Scand Suppl) Vol. 311 Pg. 103-8 ( 1984) ISSN: 0065-1591 [Print] Denmark
• PMID: 6142586 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antipsychotic Agents
• Sulpiride
• Metoclopramide

Topics

• Animals
• Antipsychotic Agents (adverse effects)
• Cebus
• Dyskinesia, Drug-Induced (drug therapy, etiology)
• Dystonia (chemically induced)
• Metoclopramide (pharmacology)
• Sulpiride (pharmacology)