A comparative double-blind study of loprazolam, 1 mg and 2 mg, versus placebo in anxiety-induced insomnia.

Abstract

A double-blind trial was carried out in 40 anxious in-patients with insomnia to compare the hypnotic effectiveness and tolerance of loprazolam, 1 mg and 2 mg, versus placebo. Groups of 10 patients received one or other dose of loprazolam or placebo for 7 nights and then placebo for the following 3 nights. Sleep quality and morning residual effects were assessed each morning during the 10-day trial period by means of a sleep questionnaire. The results showed that 1 mg loprazolam was superior to placebo but less effective than 2 mg loprazolam. No side-effects were reported at either dose level.

• Authors: P A Botter
• Journal: Current medical research and opinion (Curr Med Res Opin) Vol. 8 Issue 9 Pg. 626-30 ( 1983) ISSN: 0300-7995 [Print] England
• PMID: 6141896 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Anxiety Agents
• Benzodiazepinones
• Placebos
• Benzodiazepines
• triazulenone

Topics

• Adult
• Anti-Anxiety Agents (administration & dosage)
• Anxiety Disorders (complications)
• Benzodiazepines
• Benzodiazepinones (administration & dosage)
• Clinical Trials as Topic
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Placebos
• Random Allocation
• Sleep Initiation and Maintenance Disorders (drug therapy, etiology)