Immunohistochemical study of pheochromocytomas. An investigation of methionine-enkephalin, vasoactive intestinal peptide, somatostatin, corticotropin, beta-endorphin, and calcitonin in 16 tumors.

Abstract

Immunohistochemical investigations were carried out on 16 pheochromocytomas for a study of their immunoreactivity to methionine-enkephalin, vasoactive intestinal peptide, somatostatin, corticotropin, beta-endorphin, and calcitonin on serial semithin araldite sections. All antiserums except anti-beta-endorphin, selectively stained a variable number of distinct tumor cells. Methionine-enkephalin-immunoreactive cells were the most frequent. The neuropeptide content of pheochromocytomas appears highly diverse and unpredictable. These findings are supportive of the concept of multisecretory APUD cells of neural crest origin and rule out any of these neuropeptides as reliable immunohistochemical markers for tumor chromaffin cells.

• Authors: J Hassoun, G Monges, P Giraud, J F Henry, C Charpin, H Payan, M Toga
• Journal: The American journal of pathology (Am J Pathol) Vol. 114 Issue 1 Pg. 56-63 (Jan 1984) ISSN: 0002-9440 [Print] United States
• PMID: 6140850 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Endorphins
• Vasoactive Intestinal Peptide
• Somatostatin
• Enkephalin, Methionine
• beta-Endorphin
• Adrenocorticotropic Hormone
• Calcitonin

Topics

• Adolescent
• Adrenal Gland Neoplasms (immunology, metabolism)
• Adrenocorticotropic Hormone (immunology)
• Adult
• Calcitonin (immunology)
• Endorphins (immunology)
• Enkephalin, Methionine (immunology)
• Female
• Histocytochemistry
• Humans
• Immunoenzyme Techniques
• Male
• Middle Aged
• Pheochromocytoma (immunology, metabolism)
• Somatostatin (immunology)
• Vasoactive Intestinal Peptide (immunology)
• beta-Endorphin