The effects of single and repeated doses of maprotiline, oxaprotiline and its enantiomers on foot-shock induced fighting in rats.

Abstract

Foot-shock induced fighting behavior (SIF) in rats was tested after single and repeated dose-treatment (10 mg/kg IP twice daily for 10 days) of maprotiline, oxaprotiline and of (+)- and (-)-enantiomers of oxaprotiline. Marked facilitation of SIF was observed after repeated but not single administration of all drugs including the NA-uptake inactive (-)-enantiomer of oxaprotiline. No enhancement of SIF was seen after multiple dose-treatment with promethazine, an antihistaminic, or atropine. The mechanism of the facilitation of SIF induced by antidepressants maprotiline and oxaprotiline as well as by its enantiomers is unclear. The clear-cut dissociation of the effect of (+)- and (-)-oxaprotiline on the rate of NA-disappearance, but their similar enhancing effect on SIF challenges the assumption of a primary importance of central NA-system in this behavior. By contrast, the increase in jumping behavior recorded additionally to SIF, seems to be a great extent dependent on NA-uptake inhibiting properties of tested drugs.

• Authors: E Mogilnicka, C G Boissard, P C Waldmeier, A Delini-Stula
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 19 Issue 4 Pg. 719-23 (Oct 1983) ISSN: 0091-3057 [Print] United States
• PMID: 6139826 (Publication Type: Journal Article)

Chemical References

• Anthracenes
• Maprotiline
• hydroxymaprotilin
• Atropine
• Tyrosine 3-Monooxygenase
• Promethazine
• Norepinephrine

Topics

• Aggression (drug effects)
• Animals
• Anthracenes (pharmacology)
• Atropine (pharmacology)
• Cerebral Cortex (enzymology)
• Electroshock
• Humans
• Male
• Maprotiline (analogs & derivatives, pharmacology)
• Norepinephrine (metabolism)
• Promethazine (pharmacology)
• Rats
• Stereoisomerism
• Tyrosine 3-Monooxygenase (antagonists & inhibitors)