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Metabolism of the broad-spectrum antiviral agent, 9-(S)-(2,3-dihydroxypropyl) adenine, in different cell lines.

Abstract
9-(S)-(2,3-dihydroxypropyl)adenine [(S)-DHPA] did not undergo metabolic changes in any of the eleven cell lines tested. In these, it exhibited a varying antiviral activity against vesicular stomatitis virus (VSV), which appeared to correlate with the relative amounts of (S)-DHPA that had become cell-associated during virus infection.
AuthorsI Votruba, A Holý, E De Clercq
JournalActa virologica (Acta Virol) Vol. 27 Issue 3 Pg. 273-6 (May 1983) ISSN: 0001-723X [Print] Slovakia
PMID6138989 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Antiviral Agents
  • 9-(2,3-dihydroxypropyl)adenine
  • Adenine
Topics
  • Adenine (analogs & derivatives, metabolism, pharmacology)
  • Animals
  • Antiviral Agents (metabolism)
  • Cats
  • Cell Line
  • Chlorocebus aethiops
  • HeLa Cells
  • Humans
  • Rabbits
  • Vesicular stomatitis Indiana virus (drug effects)

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