Abstract |
An open study was carried out in 30 children with seasonal allergic rhinitis to evaluate the efficacy and tolerance of treatment with a dexbrompheniramine maleate (1.5 mg/5 ml) and pseudoephedrine sulphate (30 mg/5 ml) syrup formulation (' Disophrol' Syrup). Each patient was given 2.5 to 5 ml 4-times daily during the 14-day study period. Relief from signs and symptoms associated with seasonal rhinitis was evaluated on Days 7 and 14 of therapy. By Day 7, 5 patients were considered cured, 22 showed marked improvement and 3 patients had improved. At the Day 14 evaluation, 27 patients had complete clearing of signs and symptoms, 2 patients showed a marked improvement while the remaining patient was considered a treatment failure. Body weight and vital signs remained unaffected. Incidence of adverse reactions was limited to one occurrence of extreme fatigue, which did not necessitate termination of therapy.
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Authors | G Weippl, E Mauracher |
Journal | Pharmatherapeutica
(Pharmatherapeutica)
Vol. 3
Issue 6
Pg. 405-9
( 1983)
ISSN: 0308-051X [Print] England |
PMID | 6137833
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Drug Combinations
- Histamine H1 Antagonists
- Pyridines
- dexbrompheniramine
- Ephedrine
- Brompheniramine
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Topics |
- Adolescent
- Brompheniramine
(administration & dosage)
- Child
- Clinical Trials as Topic
- Drug Combinations
- Ephedrine
(administration & dosage)
- Female
- Histamine H1 Antagonists
(administration & dosage)
- Humans
- Male
- Pyridines
(administration & dosage)
- Rhinitis, Allergic, Seasonal
(diagnosis, drug therapy)
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