Cyclosporin improves Graves' ophthalmopathy.

Abstract

Cyclosporin given to two patients with Graves' ophthalmopathy produced a rapid objective improvement in both, including restoration of ocular-muscle function and visual acuity, improvement in exophthalmos, and reduction in orbital muscle swelling judged by computed tomographic scan. Thyroid autoantibody levels fell with treatment, and T-cell subset abnormalities returned towards normal. In one patient an absent thyrotropin response to thyrotropin-releasing hormone became normal after treatment. These results suggest that cyclospirin treatment should be considered in patients with the congestive ophthalmopathy of Graves' disease.

• Authors: A P Weetman, A M McGregor, M Ludgate, L Beck, P V Mills, J H Lazarus, R Hall
• Journal: Lancet (London, England) (Lancet) Vol. 2 Issue 8348 Pg. 486-9 (Aug 27 1983) ISSN: 0140-6736 [Print] England
• PMID: 6136647 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• Cyclosporins
• Thyroglobulin

Topics

• Acute Disease
• Autoantibodies (analysis)
• Cyclosporins (pharmacology, therapeutic use)
• Female
• Graves Disease (drug therapy, immunology)
• Humans
• Male
• Middle Aged
• Orbit (diagnostic imaging)
• T-Lymphocytes, Helper-Inducer (drug effects, immunology)
• T-Lymphocytes, Regulatory (drug effects, immunology)
• Thyroglobulin (immunology)
• Tomography, X-Ray Computed
• Visual Acuity (drug effects)