Multiple endorphins in neuronal hybrid cell lines.

Neuroblastoma x glioma hybrid cells (NG 108CC15) and tumors derived thereof were examined for dynorphin- and alpha-neoendorphin-like material. The techniques employed for analyses of opiate-like material were the isolated mouse vas deferens bioassay and gel chromatography and high pressure liquid chromatography in combination with radioimmunoassays. Dynorphin- and alpha-neoendorphin-like material was detected in both the hybrid cells and the corresponding tumors. Immunoreactive dynorphin and alpha-neoendorphin was also in NCB 20 hybrid cells and in tumors thereof assayed. In all samples investigated, the amounts of alpha-neoendorphin-like material was higher than that of dynorphin-like material. The results revealed considerable variability in the amount of dynorphin- and alpha-neoendorphin-activity between particular samples, suggesting the need for studies into the responsible mechanisms.
AuthorsR Schulz, C Gramsch, M Wüster
JournalNeuropeptides (Neuropeptides) Vol. 3 Issue 4 Pg. 271-83 (Apr 1983) ISSN: 0143-4179 [Print] SCOTLAND
PMID6135175 (Publication Type: Journal Article)
Chemical References
  • Endorphins
  • alpha-Endorphin
  • Dynorphins
  • Animals
  • Biological Assay
  • Cell Line
  • Chromatography, Gel
  • Chromatography, High Pressure Liquid
  • Dynorphins
  • Endorphins (analysis, pharmacology)
  • Glioma (analysis)
  • Hybrid Cells (analysis)
  • Male
  • Mice
  • Neuroblastoma (analysis)
  • Radioimmunoassay
  • Rats
  • Vas Deferens (drug effects)
  • alpha-Endorphin

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