Abstract |
The neuromuscular blocking characteristics and plasma concentration decay of fazadinium bromide, a short acting, non-depolarizing muscular relaxant, were simultaneously observed under standardised conditions in 6 healthy, anaesthetized, adult patients. The results were analyzed by a new pharmacodynamic model, which takes into account certain relationships describing the binding of non-depolarizing neuromuscular blocking agents and the postsynaptic receptor occupation ratio. According to the simultaneous performed, the pharmacodynamic parameters determined: KB-apparent value of equilibrium constant of fazadinium--receptors exchange (mean +/- SEM) 0.404 + 0.045 mumol/l, and the value of postsynaptic occupation ratio for 50% paralysis of 0.89 +/- 0.004 were in agreement with values reported in the literature for mammalian neuromuscular junctions in vitro. The apparent validity of the pharmacodynamic model and its value is simulating dose/effect relationships of non-depolarizing neuromuscular blocking agents are discussed and illustrated.
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Authors | A A d'Hollander, C Delcroix, P Duvaldestin, D Henzel, E Coussaert, J M Desmonts |
Journal | European journal of clinical pharmacology
(Eur J Clin Pharmacol)
Vol. 24
Issue 3
Pg. 407-13
( 1983)
ISSN: 0031-6970 [Print] Germany |
PMID | 6134623
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Humans
- Kinetics
- Male
- Models, Biological
- Muscle Contraction
(drug effects)
- Pyridinium Compounds
(metabolism, pharmacology)
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