[Effects of Prenalterol on left ventricular function of coronary patients].

Abstract

The aim of the study was to assess the effect of Prenalterol on cardiovascular beta adrenergic system of 12 coronary artery disease patients with a previous myocardial infarction. For this purpose, left ventricular function was assessed before and after intravenous administration of 30 gamma/Kg of Prenalterol, under a constant heart rate, provided by atrial pacing. Prenalterol induced a significant improvement of left ventricular contractility (dp/dt pos.-VCEmax-Vmax d), relaxation (dp/dt neg.-T constant), ventricular compliance (total diastolic compliance-modulus of chamber stiffness-end-diastolic compliance) and pump (ejection fraction) indices. These results suggest the potential usefulness of Prenalterol in severe acute cardiac failure.

• Authors: A Javernaro, R Bolognesi, P Giacometti, D Potenza, G Cortesi, F Cucchini
• Journal: Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma (Acta Biomed Ateneo Parmense) Vol. 54 Issue 1 Pg. 17-8 ( 1983) Italy
• Vernacular Title: Effetti del prenalterolo sulla funzione ventricolare sinistra del coronaropatico.
• PMID: 6134412 (Publication Type: English Abstract, Journal Article)

Chemical References

• Adrenergic beta-Agonists
• Prenalterol
• Practolol

Topics

• Adrenergic beta-Agonists (therapeutic use)
• Adult
• Heart Failure (drug therapy)
• Heart Rate (drug effects)
• Humans
• Middle Aged
• Myocardial Contraction (drug effects)
• Practolol (analogs & derivatives, therapeutic use)
• Prenalterol