Hypotensive action of a new benzimidazolinone derivative, threo-1-(2-hydroxy-2-(3,4,5-trimethoxyphenyl)-1-methylethyl)-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine (KF-4942): prazosin-like mode of action.

Abstract	Among a series of benzimidazolinone derivatives, KF-4942 was examined on its mode of hypotensive action. It was found that KF-4942 was a potent hypotensive agent, and that the hypotension was produced mostly by alpha-adrenergic blockade. Alpha-adrenergic blocking action of KF-4942 was suggested to be selective to the postsynaptic receptor. Thus, KF-4942 was concluded to be an agent with properties similar to prazosin.
Authors	A Karasawa, K Shuto, K Kubo, Y Kasuya, M Hashikami, K Shigenobu
Journal	Archives internationales de pharmacodynamie et de therapie (Arch Int Pharmacodyn Ther) Vol. 261 Issue 2 Pg. 278-90 (Feb 1983) ISSN: 0003-9780 [Print] Belgium
PMID	6132590 (Publication Type: Journal Article)
Chemical References	Adrenergic alpha-Antagonists Antihypertensive Agents Benzimidazoles Phenylephrine KF 4942 Norepinephrine Prazosin
Topics	Adrenergic alpha-Antagonists (pharmacology) Animals Antihypertensive Agents Benzimidazoles (pharmacology) Blood Pressure (drug effects) Carotid Arteries (physiology) Dogs Female In Vitro Techniques Injections, Intra-Arterial Injections, Intravenous Male Muscle Contraction (drug effects) Norepinephrine (pharmacology) Phenylephrine (pharmacology) Posture Prazosin (pharmacology) Rats Rats, Inbred Strains Regional Blood Flow (drug effects) Vertebral Artery

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