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Pharmacological effects of Ro 22-1319: a new antipsychotic agent.

Abstract
Ro 22-1319, a novel pyrroloisoquinoline compound, was identified as a potential antipsychotic agent in a rat discrete avoidance procedure that is highly specific for such agents. Results in this test are highly correlated with the clinical potency of all types of antipsychotic agents. The avoidance-blocking potency of Ro 22-1319 (0.7 mg/kg) in this procedure approached that of haloperidol (0.4 mg/kg) and was 7- and 12-times greater than that of chlorpromazine and clozapine, respectively. Ro 22-1319 exhibited similar high potency in other rat and monkey avoidance procedures, rat motor activity, and antagonism of apomorphine emesis in dogs. High potency and antipsychotic-like activity have been demonstrated in monkey EEG and in an in vivo 3H-spiroperidol binding assay. Although studies of amphetamine antagonism in rats indicate antidopaminergic activity at nigrostriatal sites, Ro 22-1319 exhibited relatively weaker cataleptogenic and antistereotypic activity than haloperidol, and had minimal activity in a rat chronic stereotypy model of receptor supersensitivity. This profile suggests that Ro 22-1319 is an efficacious antipsychotic compound, almost as potent as haloperidol, with fewer or less intense extrapyramidal effects and low potential for tardive dyskinesia.
AuthorsA B Davidson, E Boff, D A MacNeil, J Wenger, L Cook
JournalPsychopharmacology (Psychopharmacology (Berl)) Vol. 79 Issue 1 Pg. 32-9 ( 1983) ISSN: 0033-3158 [Print] Germany
PMID6132425 (Publication Type: Journal Article)
Chemical References
  • Antipsychotic Agents
  • Isoquinolines
  • Amphetamine
  • Apomorphine
  • Ro 22-1319
  • Dopamine
Topics
  • Amphetamine (antagonists & inhibitors)
  • Animals
  • Antipsychotic Agents (pharmacology)
  • Apomorphine (pharmacology)
  • Autonomic Nervous System (drug effects)
  • Avoidance Learning (drug effects)
  • Catalepsy (chemically induced)
  • Dogs
  • Dopamine (physiology)
  • Drug Interactions
  • Female
  • Hemodynamics (drug effects)
  • Humans
  • Isoquinolines (pharmacology)
  • Male
  • Motor Activity (drug effects)
  • Neurons (drug effects)
  • Rats
  • Saimiri
  • Stereotyped Behavior (drug effects)

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