Chemotherapy studies of various nitrosoureas: prevention of development of ethylnitrosourea-induced tumors in the nervous system.

Abstract

Of four nitrosoureas administered to F344 rats that were offspring of mothers treated with ethylnitrosourea during pregnancy, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea and its methyl derivative were particularly effective in blocking tumor development.

• Authors: P Paoletti, M T Giordana, S Pezzotta, D Schiffer
• Journal: National Cancer Institute monograph (Natl Cancer Inst Monogr) Vol. 46 Pg. 161-2 (Dec 1977) ISSN: 0083-1921 [Print] United States
• PMID: 613226 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Nitrogen Mustard Compounds
• Nitrosourea Compounds
• Ethylnitrosourea

Topics

• Animals
• Brain Neoplasms (chemically induced, prevention & control)
• Ethylnitrosourea
• Female
• Neoplasms, Experimental (prevention & control)
• Nitrogen Mustard Compounds
• Nitrosourea Compounds (therapeutic use)
• Pregnancy
• Rats
• Rats, Inbred F344