Chemotherapy of human nervous system tumors: influence on cerebrospinal fluid sterols.

Abstract

The cerebrospinal fluid levels of cholesterol, desmosterol, and the ratio 100 D:C taken from a study of 59 patients are reported. The patients, who had tumors of the nervous system, underwent neurosurgery, radiotherapy, and chemotherapy with 1,3-bis(2-chloroethyl)-1-nitrosourea or 1-(2-chlororethyl)-3-cyclohexyl-1-nitrosourea. The relationships among the levels of these three parameters and the clinical and neuroradiologic evolution are discussed.

• Authors: P Paoletti, S Pezzotta, A R Racca, R Fumagalli
• Journal: National Cancer Institute monograph (Natl Cancer Inst Monogr) Vol. 46 Pg. 125-6 (Dec 1977) ISSN: 0083-1921 [Print] United States
• PMID: 613223 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents
• Desmosterol
• Lomustine
• Cholesterol
• Carmustine

Topics

• Adult
• Antineoplastic Agents (pharmacology)
• Brain Neoplasms (cerebrospinal fluid, therapy)
• Carmustine (therapeutic use)
• Cholesterol (cerebrospinal fluid)
• Desmosterol (cerebrospinal fluid)
• Female
• Humans
• Lomustine (therapeutic use)
• Male
• Middle Aged