Possible role of central alpha 1-adrenoceptors in the control of the autonomic nervous system in normotensive and spontaneously hypertensive rats.

Abstract

The cardiovascular effects of AR-C 239, a new and selective alpha 1-adrenoceptor blocking drug were studied in normotensive and spontaneously hypertensive rats (SHR). AR-C 239 (300 micrograms/kg i.v.) did not change the heart rate in control (without pretreatment) and bilaterally vagotomized normotensive rats, but induced significant bradycardia in rats pretreated with a beta-adrenoceptor blocking drug. This bradycardic effect was inhibited by atropine or bilateral vagotomy. In SHR, the administration of AR-C 239 reduced heart rate in the control, bilaterally vagotomized and beta-blocked rats. Blood pressure was decreased in the same way in the two rat strains. It is suggested that central alpha 1-adrenoceptors could participate in the control of vagal tone in normotensive and SH rats, and of sympathetic activity in the SHR only.

• Authors: A M Huchet, M F Doursout, J Chelly, H Schmitt
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 85 Issue 2 Pg. 239-42 (Nov 19 1982) ISSN: 0014-2999 [Print] Netherlands
• PMID: 6129986 (Publication Type: Journal Article)

Chemical References

• Adrenergic alpha-Antagonists
• Isoquinolines
• Piperazines
• Receptors, Adrenergic
• Receptors, Adrenergic, alpha
• AR-C239

Topics

• Adrenergic alpha-Antagonists (pharmacology)
• Animals
• Autonomic Nervous System (physiopathology)
• Blood Pressure
• Heart Rate
• Hypertension (physiopathology)
• Isoquinolines (pharmacology)
• Male
• Piperazines
• Rats
• Rats, Inbred Strains
• Receptors, Adrenergic (physiology)
• Receptors, Adrenergic, alpha (physiology)