HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Pafenolol, a highly selective beta 1-adrenoceptor-antagonist, in asthmatic patients: interaction with terbutaline.

Abstract
Pafenolol, a new beta 1-adrenoceptor antagonist, has been shown in animals to be more selective for beta 1-adrenoceptors than metoprolol. It was studied in asthmatic patients to evaluate whether it was more selective with respect to circulatory effects and especially whether this selectivity influenced bronchial muscle tone less than metoprolol, which has been shown to have beta 1-adrenoceptor selectivity similar to that of atenolol. Intravenous pafenolol (5 mg and 7.5 mg), metoprolol (15 mg), and saline were given double-blind at random and thereafter four increasing doses of terbutaline were given intravenously to seven asthmatic patients with reproducible reversibility of airways obstruction. After the terbutaline dose-response curve was determined, terbutaline was inhaled three times in increasing doses. A separately reported exercise study in the same patients showed that 5 mg pafenolol and 15 mg metoprolol were equipotent with respect to beta 1-adrenoceptor blockade, whereas 7.5 mg pafenolol tended to increase the blockade. The reflex tachycardia on terbutaline stimulation after pafenolol was greater than after metoprolol due to less blockade of beta 2-adrenoceptors in peripheral blood vessels. The bronchial effect of pafenolol was equal to that of saline, but there was a difference between the terbutaline dose-response curves after pafenolol and metoprolol that caused a rightward shift of the dose-response curve. Thus, pafenolol was shown to be more beta 1-selective than metoprolol.
AuthorsC G Löfdahl, G E Marlin, N Svedmyr
JournalClinical pharmacology and therapeutics (Clin Pharmacol Ther) Vol. 33 Issue 1 Pg. 1-9 (Jan 1983) ISSN: 0009-9236 [Print] United States
PMID6129091 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Adrenergic beta-Antagonists
  • Propanolamines
  • pafenolol
  • Metoprolol
  • Terbutaline
Topics
  • Adrenergic beta-Antagonists
  • Aged
  • Asthma (drug therapy)
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Evaluation
  • Drug Interactions
  • Female
  • Heart Rate (drug effects)
  • Humans
  • Male
  • Maximal Expiratory Flow Rate
  • Metoprolol (pharmacology, therapeutic use)
  • Middle Aged
  • Propanolamines (pharmacology, therapeutic use)
  • Random Allocation
  • Terbutaline (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: