Effect of dopamine on pentagastrin-stimulated gastric antral motility in dogs with gastric fistula.

Abstract

The purpose of the present study was to evaluate the effect of dopamine on gastric antral motility in conscious dogs with gastric fistula by using miniature strain-gauge transducers. Infusion of pentagastrin changed the contractile activity to a digestive state. Dopamine, an endogenous catecholamine, was used alone and in conjunction with selective blockade or adrenergic and dopaminergic receptors. The stimulated antral motility was inhibited by dopamine. The effect was significantly blocked by the peripherally acting dopaminergic blocker domperidone and by cis-flupenthixol, which blocks both peripheral and central dopaminergic receptors. The effect of dopamine was not significantly altered by the beta 1-adrenoceptor blocker practolol, the alpha-adrenoceptor blocker phentolamine, or the alpha + beta-adrenoceptor blocker labetalol. Consequently, this study indicates that dopamine acts on gastric antral motility through dopaminergic receptors. beta-Adrenergic receptors, which are active in the impairment of gastric acid secretion, seem not to be involved in the motility response.

• Authors: K Bech, C P Hovendal, D Andersen
• Journal: Scandinavian journal of gastroenterology (Scand J Gastroenterol) Vol. 17 Issue 1 Pg. 103-7 (Jan 1982) ISSN: 0036-5521 [Print] England
• PMID: 6127786 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenergic alpha-Antagonists
• Adrenergic beta-Antagonists
• Receptors, Dopamine
• Pentagastrin
• Dopamine

Topics

• Adrenergic alpha-Antagonists (pharmacology)
• Adrenergic beta-Antagonists (pharmacology)
• Animals
• Dogs
• Dopamine (pharmacology)
• Female
• Gastrointestinal Motility (drug effects)
• Male
• Pentagastrin (pharmacology)
• Pyloric Antrum (drug effects)
• Receptors, Dopamine (drug effects)
• Stomach (physiology)