HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[The hypotensive effects and mechanism of SGB-483, a newly-synthesized hypotensive agent].

Abstract
The effects of SGB-483, a newly-synthesized hypotensive agent, on the blood pressure were studied in unanesthetized and anesthetized rats. SGB-483 produced a significant hypotensive action in the conscious SHR and renal hypertensive (clipping) rats, and it caused reversal of the pressor response to adrenaline in the anesthetized Wistar-Imamichi rats, SHR, and clipping rats. In an isolated guinea pig aorta preparation, SGB-483 competitively inhibited the contractile response to phenylephrine with a pA2 value of 7.64 +/- 0.08. In pithed rats that were pretreated with beta-adrenoceptor blocker, the pressor effect of adrenaline (1 microgram/kg) was not completely blocked by either prazosin (1 mg/kg), an alpha 1-selective blocker, or yohimbine (1 mg/kg), an alpha 2-selective blocker. SGB-483 (1 mg/kg) had no effects on the prazosin-resistant part of the pressor effect of adrenaline, but significantly inhibited the yohimbine-resistant part. Clonidine-induced reversal of the tachycardia induced in the pithed rat by cardiac sympathetic nerve stimulation was unaffected by SGB-483, indicating that SGB-483 is a selective antagonist of the alpha 1-adrenoceptor.
AuthorsW Chin, Y Nakagawa, A Mitomi, S Imai
JournalNihon yakurigaku zasshi. Folia pharmacologica Japonica (Nihon Yakurigaku Zasshi) Vol. 79 Issue 5 Pg. 441-9 (May 1982) ISSN: 0015-5691 [Print] Japan
PMID6127291 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Adrenergic alpha-Antagonists
  • Antihypertensive Agents
  • Piperazines
  • SGB 483
Topics
  • Adrenergic alpha-Antagonists
  • Anesthesia
  • Animals
  • Antihypertensive Agents (pharmacology)
  • Consciousness
  • Decerebrate State
  • Guinea Pigs
  • Hypertension (drug therapy)
  • In Vitro Techniques
  • Male
  • Muscle Contraction (drug effects)
  • Muscle, Smooth (drug effects)
  • Piperazines (pharmacology)
  • Rats
  • Rats, Inbred Strains

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: