Clinical comparison of propoxyphene napsylate and methadone in the treatment of opiate dependence.

Abstract

In this double-blind comparison of propoxyphene napsylate (PN) 800 mg in two divided doses versus methadone 20 mg, methadone 10 mg or placebo methadone, it was found that PN: 1) did not alleviate withdrawal symptoms in patients previously maintained on methadone 20 mg; 2) produced a slightly overmedicated effect in the detoxified group of exmethadone patients; and 3) compared favorably to methadone 10 mg in suppressing withdrawal symptoms without producing evidence of overmedication in those patients previously stabilized on a methadone maintenance dose of 10 mg.

• Authors: R I Wang, C Kochar, A T Hasegawa, B L Roh
• Journal: NIDA research monograph (NIDA Res Monogr) Vol. 41 Pg. 253-60 (Apr 1982) ISSN: 1046-9516 [Print] United States
• PMID: 6126814 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Dextropropoxyphene
• Methadone

Topics

• Adult
• Dextropropoxyphene (analogs & derivatives, therapeutic use)
• Double-Blind Method
• Heroin Dependence (rehabilitation)
• Humans
• Male
• Methadone (therapeutic use)
• Middle Aged
• Random Allocation
• Substance Withdrawal Syndrome (drug therapy)