Clinical comparison of propoxyphene napsylate and methadone in the treatment of opiate dependence.

In this double-blind comparison of propoxyphene napsylate (PN) 800 mg in two divided doses versus methadone 20 mg, methadone 10 mg or placebo methadone, it was found that PN: 1) did not alleviate withdrawal symptoms in patients previously maintained on methadone 20 mg; 2) produced a slightly overmedicated effect in the detoxified group of exmethadone patients; and 3) compared favorably to methadone 10 mg in suppressing withdrawal symptoms without producing evidence of overmedication in those patients previously stabilized on a methadone maintenance dose of 10 mg.
AuthorsR I Wang, C Kochar, A T Hasegawa, B L Roh
JournalNIDA research monograph (NIDA Res Monogr) Vol. 41 Pg. 253-60 (Apr 1982) ISSN: 1046-9516 [Print] UNITED STATES
PMID6126814 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Dextropropoxyphene
  • Methadone
  • Adult
  • Dextropropoxyphene (analogs & derivatives, therapeutic use)
  • Double-Blind Method
  • Heroin Dependence (rehabilitation)
  • Humans
  • Male
  • Methadone (therapeutic use)
  • Middle Aged
  • Random Allocation
  • Substance Withdrawal Syndrome (drug therapy)

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