Treatment of chronic granulocytic leukaemia in chronic phase by allogeneic marrow transplantation.

Abstract

Ten patients with chronic granulocytic leukaemia in the chronic phase have been treated with chemoradiotherapy followed by transplantation of bone marrow from HLA-identical siblings. Engraftment was achieved in all patients, and Philadelphia chromosome disappeared from the nine patients who had it before transplantation. Four patients have died, three with interstitial pneumonitis and one with severe graft-versus-host disease (GvHD). Six patients are alive and well in complete clinical, cytogenetic, and haematological remission, 1-3 years after transplantation, despite complications in three patients (one had interstitial pneumonitis, one had mild veno-occlusive disease of the liver, and one had severe GvHD).

• Authors: R A Clift, C D Buckner, E D Thomas, K Doney, A Fefer, P E Neiman, J Singer, J Sanders, P Stewart, K M Sullivan, J Deeg, R Storb
• Journal: Lancet (London, England) (Lancet) Vol. 2 Issue 8299 Pg. 621-3 (Sep 18 1982) ISSN: 0140-6736 [Print] England
• PMID: 6125772 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents
• HLA Antigens

Topics

• Adult
• Age Factors
• Antineoplastic Agents (administration & dosage)
• Bone Marrow Transplantation
• Child
• Chromosomes, Human, 21-22 and Y
• Drug Therapy, Combination
• Female
• Follow-Up Studies
• Graft vs Host Disease (mortality)
• HLA Antigens (genetics, immunology)
• Humans
• Leukemia, Myeloid (genetics, mortality, therapy)
• Male
• Postoperative Complications (mortality)
• Pulmonary Fibrosis (mortality)
• Transplantation, Isogeneic