Binding of tubocurarine, fazadinium, pancuronium and Org NC 45 to serum proteins in normal man and in patients with cirrhosis.

Abstract

The protein binding of four non-depolarizing neuromuscular blocking drugs-tubocurarine, fazadinium, pancuronium and Org NC45-was measured, in serum from normal patients and from patients with cirrhosis of the liver, by an ultracentrifugation method. The fraction bound to serum protein in normal patients was 56% for tubocurarine, 51% for fazadinium, 29% for pancuronium and 30% for Org NC 45. In patients with cirrhosis, the protein binding of the four drugs was similar to that obtained in the normal patient.

• Authors: P Duvaldestin, D Henzel
• Journal: British journal of anaesthesia (Br J Anaesth) Vol. 54 Issue 5 Pg. 513-6 (May 1982) ISSN: 0007-0912 [Print] England
• PMID: 6122460 (Publication Type: Journal Article)

Chemical References

• Blood Proteins
• Neuromuscular Nondepolarizing Agents
• Pyridinium Compounds
• Vecuronium Bromide
• Pancuronium
• Tubocurarine

Topics

• Blood Proteins (metabolism)
• Humans
• Liver Cirrhosis (blood)
• Neuromuscular Nondepolarizing Agents (blood)
• Pancuronium (analogs & derivatives, blood)
• Protein Binding
• Pyridinium Compounds (blood)
• Tubocurarine (blood)
• Vecuronium Bromide