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Sex hormone-binding globulin response to human chorionic gonadotropin stimulation in children with cryptorchidism, anorchia, male pseudohermaphroditism, and micropenis.

Abstract
Sex hormone-binding globulin serum concentrations (SHBG) were measured before and after a 5-day hCG stimulation test in 11 prepubertal boys with cryptorchidism, 6 with anorchia, 5 with male pseudohermaphroditism, and 5 with micropenis. Cryptorchid boys had decreased SHBG levels after hCG, by 55 +/- 17% (mean +/- SE) of the basal concentration. Patients with anorchia, who did not show an elevation in serum androgens, did not have decreased SHBG concentrations. Four of the 5 patients with male pseudohermaphroditism had an adequate elevation of serum androgens, did not have decreased SHBG concentrations. Four of the 5 patients with male pseudohermaphroditism had an adequate elevation of serum androgens after hCG, but in only 3 of them did SHBG decrease. None of the 5 patients with micropenis had decreased serum SHBG levels despite normal increments in serum androgens. The administration of a long-acting preparation of testosterone to sexually infantile subjects produce a similar decrease in the SHBG concentration. This change in SHBG concentration after hCG or testosterone in prepubertal boys could be used as a convenient test of biological response to androgens.
AuthorsA Belgorosky, M A Rivarola
JournalThe Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 54 Issue 4 Pg. 698-704 (Apr 1982) ISSN: 0021-972X [Print] United States
PMID6120946 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Chorionic Gonadotropin
  • Hydroxysteroids
  • Sex Hormone-Binding Globulin
  • Testosterone
Topics
  • Adolescent
  • Child
  • Child, Preschool
  • Chorionic Gonadotropin
  • Cryptorchidism (physiopathology)
  • Disorders of Sex Development (physiopathology)
  • Gonadal Dysgenesis (physiopathology)
  • Humans
  • Hydroxysteroids (blood)
  • Male
  • Penis (abnormalities)
  • Sex Hormone-Binding Globulin (metabolism)
  • Testis (abnormalities)
  • Testosterone

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