Abstract |
Sex hormone-binding globulin serum concentrations (SHBG) were measured before and after a 5-day hCG stimulation test in 11 prepubertal boys with cryptorchidism, 6 with anorchia, 5 with male pseudohermaphroditism, and 5 with micropenis. Cryptorchid boys had decreased SHBG levels after hCG, by 55 +/- 17% (mean +/- SE) of the basal concentration. Patients with anorchia, who did not show an elevation in serum androgens, did not have decreased SHBG concentrations. Four of the 5 patients with male pseudohermaphroditism had an adequate elevation of serum androgens, did not have decreased SHBG concentrations. Four of the 5 patients with male pseudohermaphroditism had an adequate elevation of serum androgens after hCG, but in only 3 of them did SHBG decrease. None of the 5 patients with micropenis had decreased serum SHBG levels despite normal increments in serum androgens. The administration of a long-acting preparation of testosterone to sexually infantile subjects produce a similar decrease in the SHBG concentration. This change in SHBG concentration after hCG or testosterone in prepubertal boys could be used as a convenient test of biological response to androgens.
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Authors | A Belgorosky, M A Rivarola |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 54
Issue 4
Pg. 698-704
(Apr 1982)
ISSN: 0021-972X [Print] United States |
PMID | 6120946
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chorionic Gonadotropin
- Hydroxysteroids
- Sex Hormone-Binding Globulin
- Testosterone
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Topics |
- Adolescent
- Child
- Child, Preschool
- Chorionic Gonadotropin
- Cryptorchidism
(physiopathology)
- Disorders of Sex Development
(physiopathology)
- Gonadal Dysgenesis
(physiopathology)
- Humans
- Hydroxysteroids
(blood)
- Male
- Penis
(abnormalities)
- Sex Hormone-Binding Globulin
(metabolism)
- Testis
(abnormalities)
- Testosterone
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