[Somatostatin in a case of nesidioblastosis (author's transl)].

Abstract

The authors report the case of a three-month-old infant presenting with hypoglycaemia. The etiology, i.e. nesidioblastosis, was asserted by simultaneous dosage of insulin and glucose and by histologic study of the pancreas. Initial therapy was a combination of diazoxide, continuous enteral alimentation and glucose injections. It's ineffectiveness led to an operative decision and 4/5 ths of the pancreas were removed. After a transitory improvement symptoms recurred. Data provided by studies of baseline levels and response to exogenous somatostatin then allowed to determine the correct dosage for treatment with long-acting somatostatin. The authors also discuss the importance of somatostatin in pathogenesis as well as for diagnosis and therapy of nesidioblasosis.

• Authors: M Petrus, G Dutau, P Rochiccioli
• Journal: La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris (Sem Hop) 1981 Dec 18-25 Vol. 57 Issue 47-48 Pg. 2036-8 France
• Vernacular Title: Etude de la somatostatine dans un cas d'hyperinsulinisme sév 53ere par nésidioblastose.
• PMID: 6120572 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Somatostatin

Topics

• Humans
• Hyperinsulinism (diagnosis, etiology)
• Infant, Newborn
• Male
• Pancreatic Diseases (drug therapy, pathology)
• Somatostatin (therapeutic use)