Effects of bucumolol, a beta-adrenergic blocking agent, and its d-isomer on myocardial infarction produced by coronary artery ligation in rats.

Abstract

Acute ligation of the left coronary artery of rats produced abnormal Q-wave in the electrocardiogram, tachycardia and frequent ventricular fibrillation. Serum CPK level was elevated, reaching a maximum at 3 to 5 hours after ligation and returning to near the pre-ligation level 24 hours later, when CPK activity in the left ventricle markedly decreased. Pretreatment with bucumolol at 2.5 mg/Kg s.c. and 5 mg/Kg s.c. lessened these changes and increased the survival rate in a dose related manner. d-Bucumolol at 5 mg/Kg, on the other hand, increased survival rate primarily by suppressing ventricular fibrillation without any significant effect on other parameters. These results suggest that the membrane stabilizing action does not contribute to protective actions of bucumolol against myocardial ischemia.

• Authors: H Koike, S Kumakura, H Nishino, H Tamaoki, S Minato
• Journal: Japanese heart journal (Jpn Heart J) Vol. 22 Issue 5 Pg. 815-23 (Sep 1981) ISSN: 0021-4868 [Print] Japan
• PMID: 6119377 (Publication Type: Journal Article)

Chemical References

• Adrenergic beta-Antagonists
• Coumarins
• Propanolamines
• Creatine Kinase
• bucumolol

Topics

• Adrenergic beta-Antagonists (therapeutic use)
• Animals
• Coronary Circulation (drug effects)
• Coumarins (therapeutic use)
• Creatine Kinase (blood)
• Disease Models, Animal
• Electrocardiography
• Heart Rate (drug effects)
• Male
• Myocardial Infarction (drug therapy)
• Myocardium (enzymology)
• Propanolamines
• Rats
• Rats, Inbred Strains
• Stereoisomerism
• Ventricular Fibrillation (prevention & control)