Actions of non-cardiodepressant beta-adrenergic blocking agents in hemorrhagic shock.

Abstract

Two new beta-adrenergic blocking agents, timolol and MK-761, were found to effectively antagonize the positive inotropic effects of isoproterenol on isolated cat papillary muscles without depressing contractile force. However, appropriate doses of these beta-adrenergic blockers (ie, 12.5--25 microgram/kg) did not significantly prolong survival in hemorrhagic shock in anesthetized cats. MK-761 prevented some of the plasma accumulations of myocardial depressant factor (MDF) during shock. Nevertheless both beta-blockers failed to prevent the accumulation of the lysosomal protease cathepsin D or peptide fragments (ie, amino-nitrogen groups) in the blood during shock. We conclude that neither agent is of significant benefit in severe hemorrhagic shock, and probably beta-adrenergic blockade is not a productive approach to pursue in the therapeutics of hemorrhagic shock.

• Authors: A M Lefer, D J Lefer, R J Levin
• Journal: Advances in shock research (Adv Shock Res) Vol. 3 Pg. 167-74 ( 1980) ISSN: 0195-878X [Print] United States
• PMID: 6118024 (Publication Type: Journal Article)

Chemical References

• Adrenergic beta-Antagonists
• Myocardial Depressant Factor
• Propanolamines
• Pyridines
• MK 761
• Timolol
• Isoproterenol

Topics

• Adrenergic beta-Antagonists (therapeutic use)
• Animals
• Cats
• In Vitro Techniques
• Isoproterenol (pharmacology)
• Male
• Myocardial Contraction (drug effects)
• Myocardial Depressant Factor
• Propanolamines (therapeutic use)
• Pyridines (pharmacology, therapeutic use)
• Shock, Hemorrhagic (blood, drug therapy, physiopathology)
• Timolol (pharmacology, therapeutic use)