[Possible malignant hyperthermia as reaction to an overdose of myotonolytic, antidepressive and sedative drugs (author's transl)].

Abstract

A 51-year-old male patient with no history of musculo-skeletal or myopathic abnormalities, but suffering from manic-depressive psychosis, attempted suicide with an overdose of dolpersin hydrochloride (Mydocalm), dipenzepine hydrochloride (Noveril), meprobamate (Mepronox) and nitrazepam (Mogadon). He developed high fever, muscle rigidity, tachycardia, arrhythmias, hypotension and mottled cyanosis, symptoms well-known in persons with malignant hyperthermia, an autosomally inherited disease of skeletal muscle. There is also discussed the manifestation and the symptoms of an acute rhabdomyolysis. The diagnosis was confirmed by chemical pathological laboratory findings, including respiratory and metabolic acidosis, myoglobinaemia accompanied by myoglobin diuresis, and elevated creatine phosphokinase (CPK values up to 2790 U/l). Electron microscopic examination of muscle tissue revealed signs of myolysis and mitochondrial reactions with pleoconic hyperplasia. No inhalation anaesthetics or skeletal muscle relaxants, such as succinyl choline, were used in this case. Therefore, malignant hyperthermia might have been induced by a combination of drugs which were not known to induce this abnormal muscular reaction. However, the muscle relaxant effect of dolpersin hydrochloride may have acted as a possible inducer of the attack.

• Authors: J M Hackl, J Engl, F Hofstädter, S Bonelli, E Rumpl, E Dworzak, B Puschendorf
• Journal: Wiener klinische Wochenschrift (Wien Klin Wochenschr) Vol. 93 Issue 15 Pg. 475-9 (Aug 07 1981) ISSN: 0043-5325 [Print] Austria
• Vernacular Title: Fragliche maligne Hyperthermiekrise bei Medikamentenintoxikation.
• PMID: 6117987 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Dibenzazepines
• Psychotropic Drugs
• Nitrazepam
• Meprobamate
• Tolperisone

Topics

• Bipolar Disorder (psychology)
• Dibenzazepines (poisoning)
• Electromyography
• Heart Rate (drug effects)
• Humans
• Male
• Malignant Hyperthermia (etiology)
• Meprobamate (poisoning)
• Microscopy, Electron
• Middle Aged
• Mitochondria, Muscle (drug effects)
• Muscles (drug effects)
• Nitrazepam (poisoning)
• Psychotropic Drugs (poisoning)
• Suicide, Attempted (psychology)
• Tolperisone (poisoning)