Bombesin, somatostatin, and related peptides: actions on thermoregulation.

Abstract

Bombesin acts within the anterior hypothalamic preoptic area to interfere with thermoregulation in the rat. The body temperature (Tb) of animals receiving bombesin varies in parallel with ambient temperature (Ta). Bombesin-induced reduction of Tb in animals at low Ta is associated with a marked reduction of oxygen consumption (VO2). Some somatostatin-related peptides, e.g., desAA 1,2,4,5,12,13 [D-Trp8]-somatostatin (ODT8-SS), act within the brain to prevent bombesin-induced reduction of VO2 and Tb. ODT8-SS also produces hyperthermia not associated with an increase in VO2.

• Authors: M R Brown
• Journal: Federation proceedings (Fed Proc) Vol. 40 Issue 13 Pg. 2765-8 (Nov 1981) ISSN: 0014-9446 [Print] United States
• PMID: 6117485 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Peptides
• Prostaglandins E
• Somatostatin
• Gastrin-Releasing Peptide
• Dinoprostone
• Bombesin

Topics

• Animals
• Body Temperature Regulation (drug effects)
• Bombesin (pharmacology)
• Dinoprostone
• Gastrin-Releasing Peptide
• Hypothalamus (drug effects, physiology)
• Peptides (pharmacology)
• Prostaglandins E (pharmacology)
• Rats
• Somatostatin (analogs & derivatives, pharmacology)
• Structure-Activity Relationship