Abstract |
1 The effect of i.v. rimiterol was compared with aerosol rimiterol in twelve asthmatic patients. 2 A cumulative dose of rimiterol (1050 microgram) given in six separate injections over 90 min resulted in a mean increase in peak expiratory flow rate (PEFR) of 50.6% and FEV1 of 53.7%. 3 Comparison of the degree of bronchodilation to the same dose of rimiterol administered intravenously or by aerosol, suggested that on average the potency ratio was 10:1, i.e. ten times the aerosol dose was required to produce the equivalent bronchodilator effect. 4 Palpitations, tremor and postural hypotension were common during the first minute after the drug was injected intravenously, but did not occur after aerosol administration. 5 It is suggested that rimiterol by intravenous injection is a useful addition to the treatment of acute asthma.
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Authors | R A Tarala, V Martyn, J W Paterson |
Journal | British journal of clinical pharmacology
(Br J Clin Pharmacol)
Vol. 12
Issue 3
Pg. 333-40
(Sep 1981)
ISSN: 0306-5251 [Print] England |
PMID | 6117302
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Catechols
- Piperidines
- rimiterol
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Topics |
- Adult
- Aged
- Asthma
(drug therapy, physiopathology)
- Blood Pressure
(drug effects)
- Catechols
(administration & dosage)
- Female
- Forced Expiratory Volume
- Heart Rate
(drug effects)
- Humans
- Injections, Intravenous
- Male
- Middle Aged
- Piperidines
(administration & dosage, adverse effects)
- Vital Capacity
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