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Effect of intravenous injection of rimiterol in asthma.

Abstract
1 The effect of i.v. rimiterol was compared with aerosol rimiterol in twelve asthmatic patients. 2 A cumulative dose of rimiterol (1050 microgram) given in six separate injections over 90 min resulted in a mean increase in peak expiratory flow rate (PEFR) of 50.6% and FEV1 of 53.7%. 3 Comparison of the degree of bronchodilation to the same dose of rimiterol administered intravenously or by aerosol, suggested that on average the potency ratio was 10:1, i.e. ten times the aerosol dose was required to produce the equivalent bronchodilator effect. 4 Palpitations, tremor and postural hypotension were common during the first minute after the drug was injected intravenously, but did not occur after aerosol administration. 5 It is suggested that rimiterol by intravenous injection is a useful addition to the treatment of acute asthma.
AuthorsR A Tarala, V Martyn, J W Paterson
JournalBritish journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 12 Issue 3 Pg. 333-40 (Sep 1981) ISSN: 0306-5251 [Print] England
PMID6117302 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Catechols
  • Piperidines
  • rimiterol
Topics
  • Adult
  • Aged
  • Asthma (drug therapy, physiopathology)
  • Blood Pressure (drug effects)
  • Catechols (administration & dosage)
  • Female
  • Forced Expiratory Volume
  • Heart Rate (drug effects)
  • Humans
  • Injections, Intravenous
  • Male
  • Middle Aged
  • Piperidines (administration & dosage, adverse effects)
  • Vital Capacity

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