Abstract |
In 20 patients with stable angina pectoris, o-[3-(tert.-butylamino)-2-hydroxypropoxy]- benzonitrile ( bunitrolol) was compared with placebo in a double blind cross-over trial, with monthly treatment periods. There was no difference in the subjective condition of the patient. The bunitrolol treated patients showed a significantly better work capacity (P less than 0.05) and pressure-rate product (P less than 0.01) in the exercise tests. No significant difference could be found in the ST-segment changes. The bunitrolol patients showed a significant reduction in heart rate at rest (P less than 0.01); a significant difference in blood pressure was not found. Bunitrolol is an effective beta-adrenergic blocker, without side-effects in this trial.
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Authors | J J Jonker, J de Klerk, G J den Ottolander |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 31
Issue 7
Pg. 1140-2
( 1981)
ISSN: 0004-4172 [Print] Germany |
PMID | 6115654
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adult
- Aged
- Angina Pectoris
(drug therapy)
- Blood Pressure
(drug effects)
- Double-Blind Method
- Drug Evaluation
- Electrocardiography
- Exercise Test
- Heart Rate
(drug effects)
- Humans
- Middle Aged
- Placebos
- Propanolamines
(therapeutic use)
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