Clinical significance of glucagon provocation test in the diagnosis of hypergastrinemia.

Abstract

Glucagon provocation test was performed in the patients with hypergastrinemia and hyperchlorhydria to investigate its diagnostic value. A paradoxical response of plasma gastrin level in the patients with the Zollinger-Ellison syndrome and a marked decrease of plasma gastrin level in the patients with gastric ulcer, duodenal ulcer, excluded gastric antrum, multiple endocrine adenomatosis, pernicious anemia and chronic renal failure were demonstrated by glucagon infusion. Glucagon provocation test, therefore, was considered to be of great value in the diagnosis of the Zollinger-Ellison syndrome, particularly, in the case of an excluded gastric antrum in which secretin provocation test caused the false positive result because of a marked increase of pancreatic secretion. Glucagon provocation test in combination with secretin provocation test, therefore, is at present the most preferable diagnostic procedure for detecting the Zollinger-Ellison syndrome.U

• Authors: C Nakanome, A Ishimori, Y Goto, T Yamazaki, J Kameyama, I Sasaki, M Inui, Y Furukawa, K Komatsu
• Journal: Gastroenterologia Japonica (Gastroenterol Jpn) Vol. 16 Issue 3 Pg. 213-22 ( 1981) ISSN: 0435-1339 [Print] Japan
• PMID: 6114893 (Publication Type: Case Reports, Journal Article)

Chemical References

• Gastrins
• Secretin
• Glucagon

Topics

• Adult
• Diagnosis, Differential
• Duodenal Ulcer (diagnosis)
• Female
• Gastrectomy
• Gastrins (blood)
• Glucagon
• Humans
• Kidney Failure, Chronic (diagnosis)
• Middle Aged
• Multiple Endocrine Neoplasia (diagnosis)
• Pyloric Antrum
• Secretin
• Stomach Ulcer (diagnosis)
• Zollinger-Ellison Syndrome (diagnosis)