Adverse effects of commonly ordered oral narcotics.

Approximately equianalgesic oral doses of codeine, an oxycodone compound resembling Percodan, and pentazocine were compared for adverse effects in a double-blind, randomized study of four doses of each drug given over two days to 247 postsurgical patients with pain. Placebo and parenteral morphine were also treated as negative and positive controls, respectively. Approximately 50 patients each received one of the five drugs. Codeine, pentazocine, and morphine had the same incidence of adverse effects (22 to 28 per cent). One capsule of oxycodone compound was the analgesic equivalent of 12.5 mg morphine with an adverse effect incidence of 4 per cent (placebo 8 per cent). Smoking made no difference in analgesic effect or adverse effects. Analgesics given in the evening intervening between the two days may have affected the analgesic performance of placebo.
AuthorsT G Kantor, M Hopper, E Laska
JournalJournal of clinical pharmacology (J Clin Pharmacol) Vol. 21 Issue 1 Pg. 1-8 (Jan 1981) ISSN: 0091-2700 [Print] UNITED STATES
PMID6111570 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Analgesics, Opioid
  • Morphine
  • Oxycodone
  • Codeine
  • Pentazocine
  • Administration, Oral
  • Adult
  • Aged
  • Analgesics, Opioid (administration & dosage, adverse effects)
  • Clinical Trials as Topic
  • Codeine (adverse effects)
  • Dizziness (chemically induced)
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Morphine (adverse effects)
  • Nausea (chemically induced)
  • Oxycodone (adverse effects)
  • Pentazocine (adverse effects)
  • Sleep Stages (drug effects)

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