Effect of N, N'-bis(methylisatin-beta-thiosemicarbazone)-2-methylpiperazine against virus-induced encephalitis in mice).

Abstract

N,N'-bis(methylisatin-beta-thiosemicarbazone)-2-methylpiperazine (TSKI-VI) proved to be significantly effective against lethal vaccinia, pseudorabies and Mengo virus-induced encephalitis in different strains of mice when administered subcutaneously (s.c.) in doses of 20 mg/kg body weight, twice daily, for a period of five days. The strongest effects occurred in vaccinia virus-infected mice, and the degree of protection was both dose- and virus-dependent. Titres of vaccinia virus in brains of infected mice were slightly lower in TSKI-VI or methisazone-treated mice as compared to virus controls.

• Authors: I Zgórniak-Nowosielska, A Gatkiewicz, A Veckenstedt, I Béládi
• Journal: Acta virologica (Acta Virol) Vol. 24 Issue 6 Pg. 439-44 (Dec 1980) ISSN: 0001-723X [Print] Slovakia
• PMID: 6111204 (Publication Type: Journal Article)

Chemical References

• Piperazines
• Thiosemicarbazones
• TSKI-VI
• Methisazone

Topics

• Animals
• Dose-Response Relationship, Drug
• Encephalitis (drug therapy)
• Enterovirus Infections (drug therapy)
• Female
• Male
• Mengovirus
• Methisazone (analogs & derivatives, therapeutic use)
• Mice
• Mice, Inbred BALB C
• Mice, Inbred Strains
• Piperazines (therapeutic use)
• Pseudorabies (drug therapy)
• Thiosemicarbazones (therapeutic use)
• Vaccinia (drug therapy)