Effects of topical use of beta-adrenoceptor stimulants of nasal mucosa. Rhinomanometric evaluations in experiments with terbutaline and KWD 2131.

Abstract

The effects of nasal airway resistance of the beta-adrenoceptor stimulants terbutaline (Bricanyl) and KWD 2131 intranasally have been studied by means of posterior rhinomanometry in 16 healthy volunteers and 13 asymptomatic patients with allergic rhinitis. The study was performed as randomized, placebo-controlled, double-blind crossover trial. No obvious changes in nasal resistance were revealed. This makes the nasal muscosa a suitable organ for testing the capacity of beta-adrenoceptor stimulants to reduce the release of mediators from mast cells after allergen challenges.

• Authors: G Svensson, B Hegardt, T Löfkvist
• Journal: Acta oto-laryngologica (Acta Otolaryngol) 1980 Sep-Oct Vol. 90 Issue 3-4 Pg. 297-303 ISSN: 0001-6489 [Print] England
• PMID: 6110308 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Adrenergic beta-Agonists
• KWD 2131
• Terbutaline

Topics

• Administration, Topical
• Adolescent
• Adrenergic beta-Agonists (pharmacology)
• Adult
• Airway Resistance (drug effects)
• Clinical Trials as Topic
• Double-Blind Method
• Female
• Humans
• Male
• Nasal Mucosa (drug effects)
• Rhinitis, Allergic, Seasonal (physiopathology)
• Terbutaline (administration & dosage, analogs & derivatives, pharmacology)