Relationship of biosynthesis of slow reacting substance to intracellular glutathione concentrations.

Abstract

To further elucidate the role of glutathione (GSH) in the biosynthesis of slow reacting substance (SRS), SRS generation was studied in rat basophilic leukemia cells that had been preincubated with 2-cyclohexen-1-one or diethyl maleate to decrease their intracellular GSH concentrations. At low GSH levels SRS formation was markedly inhibited. The formation of other lipoxygenase products was much less affected, although some decrease in 5-hydroxyicosatetraenoic acid formation also occurred, apparently due in part to less rapid reduction of the 5-hydroperoxide.

• Authors: C W Parker, C M Fischman, H J Wedner
• Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 77 Issue 11 Pg. 6870-3 (Nov 1980) ISSN: 0027-8424 [Print] United States
• PMID: 6109285 (Publication Type: Journal Article)

Chemical References

• Arachidonic Acids
• Autacoids
• Cyclohexanones
• Maleates
• Prostaglandins D
• 2-cyclohexen-1-one
• diethyl maleate
• Glutathione

Topics

• Animals
• Arachidonic Acids (metabolism)
• Autacoids (biosynthesis)
• Cells, Cultured
• Cyclohexanones (pharmacology)
• Glutathione (metabolism)
• Leukemia, Experimental (metabolism)
• Maleates (pharmacology)
• Prostaglandins D (metabolism)
• Rats