[Characteristics of the anticonvulsant effects of fenazepam].

Abstract

Studies of the new benzodiazepine drug phenazepam comparatively to diazepam, clonazepam, nitrazepam, phenobarbital and diphenylhydantoin have shown that by its anticonvulsant effects phenazepam is similar to clonazepam and differs from other antiepileptic agents. Phenazepam exhibits a pronounced capacity for removing paroxysmal epileptiform discharges induced by cobalt application to the surface of the brain cortex. Prolonged administration induces tolerance to phenazepam as shown by antagonism to strychnine and by capacity for preventing convulsions in maximal electric shock.

• Authors: T A Voronina, T L Garibova, L N Nerobkova
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1980 Sep-Oct Vol. 43 Issue 5 Pg. 546-51 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Kharakteristika protivosudorozhnykh éffektov fenazepama.
• PMID: 6108867 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Anxiety Agents
• Anticonvulsants
• Benzodiazepinones
• Benzodiazepines
• phenazepam

Topics

• Animals
• Anti-Anxiety Agents (therapeutic use)
• Anticonvulsants
• Benzodiazepines
• Benzodiazepinones (therapeutic use)
• Drug Evaluation, Preclinical
• Drug Tolerance
• Electroencephalography
• Male
• Mice
• Rats
• Seizures (chemically induced, drug therapy, physiopathology)
• Time Factors