Effect of two types of beta-adrenergic blockade on gastric acid secretion during basal conditions and during histamine stimulation on non-vagotomized and in vagotomized gastric fistula dogs.

Abstract	The effect of beta-adrenoreceptor blockade by propranolol and practolol on basal secretion and on submaximally histamine-stimulated gastric acid secretion was studied in conscious non-vagotomized and in vagotomized gastric fistula dogs. Neither propranolol (0.5 mg/kg) nor practolol (1.0 mg/kg), both intravenously, had a significant influence on basal or histamine-stimulated gastric acid secretion in non-vagotomized and vagotomized dogs. It is concluded that beta-adrenergic blockade has no influence on basal or histamine-stimulated gastric acid secretion in dogs. Furthermore, no differences were found between the non-vagotomized and the vagotomized stomach.
Authors	F Gottrup, D Andersen, H Stødkilde Jørgensen
Journal	Scandinavian journal of gastroenterology (Scand J Gastroenterol) Vol. 15 Issue 5 Pg. 555-9 ( 1980) ISSN: 0036-5521 [Print] England
PMID	6108604 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Adrenergic beta-Antagonists Histamine Propranolol Practolol
Topics	Adrenergic beta-Antagonists (pharmacology) Animals Dogs Female Gastric Acid (metabolism) Gastric Fistula (physiopathology) Histamine (pharmacology) Male Practolol (pharmacology) Propranolol (pharmacology) Pulse (drug effects) Secretory Rate (drug effects) Vagotomy

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