The comparison of the effects of DL-308, a potential new neuroleptic agent, and thioridazine on some psychological and physiological functions in healthy volunteers.

Abstract

Eight healthy male volunteers participated in four experimental sessions in which they ingested either DL-308 (10 mg), DL-308 (20 mg), thioridazine (50 mg) or placebo. Drugs were allocated to subjects and sessions in a double-blind fashion according to a balanced cross-over design. Both DL-308 and thioridazine displayed sedative properties, as indicated by the sedated appearance of the subjects, by a decrease in subjectively rated alertness and by an impairment of performance on psychomotor tests. DL-308 appeared to be a more potent sedative than thioridazine. DL-308 (10 mg) caused an increase in subjectivey rated sweating and objectively measured heart rate, suggesting a sympathomimetic property for the drug. DL-308, similarly to thioridazine, had effects consistent with an alpha-adrenolytic action; both drugs caused miosis, hypotension and a decrease in salivation. The decrease in salivation may also be consistent with an anticholinergic effect. When equisedative doses of the two drugs were compared, DL-308 had a much smaller influence on autonomic functions than thioridazine. DL-308 had a faster time-course of action than thioridazine. Peak effects were attained 1-3 h post-drug and the effects almost completely dissipated within 5 h. DL-308, similarly to thioridazine, had little effect on the motor system, as indicated by conventional clinical neurological examination.

• Authors: E Szabadi, C M Bradshaw, P Gaszner
• Journal: Psychopharmacology (Psychopharmacology (Berl)) Vol. 68 Issue 2 Pg. 125-34 ( 1980) ISSN: 0033-3158 [Print] Germany
• PMID: 6107945 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antipsychotic Agents
• Imidazoles
• zetidoline
• Thioridazine

Topics

• Adult
• Antipsychotic Agents (pharmacology)
• Autonomic Nervous System (drug effects)
• Emotions (drug effects)
• Hemodynamics (drug effects)
• Humans
• Imidazoles (pharmacology)
• Intelligence Tests
• Male
• Motor Skills (drug effects)
• Pupil (drug effects)
• Salivation (drug effects)
• Thioridazine (pharmacology)