Coxsackie-B-virus-specific IgM responses in patients with cardiac and other diseases.

Abstract

An enzyme-linked immunosorbent assay (ELISA) test using polyvalent antigens and antisera was developed to detect Coxsackie-B-virus-specific IgM responses. The sera of 24 of 64 (37.5%) patients with acute pericarditis and 14 of 38 (36%) with acute myocarditis were positive for Coxsackie-B-virus-specific IgM. 4 of 30 (13.3%) patients with acute ischaemic heart disease and 2 of 28 (7.1%) patients with congestive cardiomyopathy were also positive. Coxsackie-B-virus-specific IgM was detected in the sera of 21 of 57 (36.8%) patients with Bornholm disease and 2 of 4 patients with acute-onset juvenile diabetes. Coxsackie-B-virus-specific IgM responses persisted for 6-8 weeks. Sera from patients with chronic valvular heart disease, Mycoplasma pneumoniae infections, and virus infections caused by viruses other than Coxsackie-B viruses were all negative. False-positive results did not occur when sera containing high titres of rheumatoid factor were tested.

• Authors: M M El-Hagrassy, J E Banatvala, D J Coltart
• Journal: Lancet (London, England) (Lancet) Vol. 2 Issue 8205 Pg. 1160-2 (Nov 29 1980) ISSN: 0140-6736 [Print] England
• PMID: 6107769 (Publication Type: Journal Article)

Chemical References

• Antibodies, Viral
• Immunoglobulin M

Topics

• Acute Disease
• Adolescent
• Adult
• Aged
• Antibodies, Viral (analysis)
• Child
• Child, Preschool
• Diabetes Mellitus, Type 1 (immunology)
• Enterovirus B, Human (immunology)
• Enzyme-Linked Immunosorbent Assay
• Female
• Heart Diseases (immunology)
• Humans
• Immunoglobulin M (analysis)
• Male
• Meningitis, Aseptic (immunology)
• Middle Aged
• Myocarditis (immunology)
• Pericarditis (immunology)
• Pleurodynia, Epidemic (immunology)
• Species Specificity