[Low diuretic dosage in a beta blocker-diuretic combination].

Abstract

Thirty outpatients with arterial hypertension were treated for eight weeks with a daily dose of one tablet of Cardiotensin, taken after breakfast. The compound contains 100mg bupranolol, 10mg bemetizide and 20mg triamterene. Drug therapy was preceded by a one-week placebo washout period. Within two weeks of treatment, systolic and diastolic blood pressure had reverted to normal in 26 of the patients. At the end of the observation period, 4 patients still had diastolic pressure values of more than 100 mm Hg. Ergometer stress testing revealed clear-cut diminution of blood pressure and heart rate elevations following the medication. Serum potassium levels were not influenced by the drug. Under the mentioned dose regimen there were no changes in serum uric acid, creatinine, and glucose concentrations. Tolerability was generally good.

• Authors: H J Liewald, A Schrey, R Grund
• Journal: Medizinische Klinik (Med Klin) Vol. 75 Issue 18 Pg. 654-7 (Aug 29 1980) ISSN: 0025-8458 [Print] Germany
• Vernacular Title: Niedrige Diuretika-Dosierung in einer Betablocker-Diuretika-Kombination.
• PMID: 6106884 (Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Adrenergic beta-Antagonists
• Antihypertensive Agents
• Benzothiadiazines
• Diuretics
• Drug Combinations
• Sodium Chloride Symporter Inhibitors
• Tablets
• Bupranolol
• dehydrosanol
• Triamterene

Topics

• Administration, Oral
• Adrenergic beta-Antagonists (administration & dosage)
• Adult
• Aged
• Antihypertensive Agents (administration & dosage)
• Benzothiadiazines (administration & dosage)
• Bupranolol (administration & dosage)
• Diuretics (administration & dosage)
• Drug Combinations
• Female
• Humans
• Hypertension (drug therapy)
• Male
• Middle Aged
• Sodium Chloride Symporter Inhibitors (administration & dosage)
• Tablets
• Triamterene (administration & dosage)