TRH-induced hyperprolactinemia and pituitary-ovarian function.

Abstract

To elucidate the role of prolactin in the control of pituitary-ovarian function, eight healthy women were given 80 mg of synthetic thyrotropin-releasing hormone (TRH) orally on two consecutive days during the luteal phase of their menstrual cycle. TRH elevated serum prolactin to a mean concentration of 43.8 ng/ml on the first day and to 15.5 ng/ml on the second day. The reduced response to the second TRH dose was statistically significant (p < 0.05). Accompanying changes in concentrations of gonadotropins or ovarian steroids were not consistent. Short-term oral administration of TRH and/or the temporary hyperprolactinemia induced by its use do not modify the pituitary-ovarian function during the luteal phase of the menstrual cycle.

• Authors: O Ylikorkala, M Y Dawood, S Kivinen
• Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) 1980 May-Jun Vol. 17 Issue 6 Pg. 577-80 ISSN: 0020-7292 [Print] United States
• PMID: 6106576 (Publication Type: Journal Article)

Chemical References

• Thyrotropin-Releasing Hormone
• Prolactin

Topics

• Adult
• Blood Chemical Analysis
• Female
• Humans
• Ovary (physiology)
• Pituitary Gland (physiology)
• Prolactin (physiology)
• Thyrotropin-Releasing Hormone (physiology)