[Effect of quateron on the dopamine and DOPA content in the stomach tissues in experimental ulcer].

Abstract

Experimental neurogenous ulcer is accompanied by changes in the content of dopamin (DA) and dioxypyhenylalanine (DOPA) in the tissues of different functional regions of the stomach. Two hours following injury to the pyloroduodenal region, the content of DA rises, while that of DOPA declines. After 24 hours the content of the monoamine and especially that of the amino acid decreases along with emergence and development of morphological changes (hemorrhages, erosions, ulcers) in the gastric wall. The cholinolytic quateron administered prior to the injury prevents reliably the affection of the gastric mucosa and blocks to a certain measure DOPA depletion which is recorded 24 hours following exposure to the pathogenetic agent. The utiulcerous effect of quateron is potentiated by DOPA administration (100 mg/kg).

• Authors: S A Mirzoian, T L Virabian
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1980 Jan-Feb Vol. 43 Issue 1 Pg. 71-4 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Vliianie kvaterona na soderzhanie dofamina i DOFA v tkaniakh zheludka pri ego éksperimental'noĭ iazve.
• PMID: 6103821 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Benzoates
• Ganglionic Blockers
• Quaternary Ammonium Compounds
• quateron
• Dihydroxyphenylalanine
• Dopamine

Topics

• Animals
• Benzoates (therapeutic use)
• Dihydroxyphenylalanine (metabolism)
• Dopamine (metabolism)
• Drug Evaluation, Preclinical
• Ganglionic Blockers (therapeutic use)
• Gastric Mucosa (metabolism)
• Quaternary Ammonium Compounds (therapeutic use)
• Rats
• Stomach (drug effects)
• Stomach Ulcer (drug therapy, metabolism)
• Time Factors