Evaluation of BL-P1654: a semisynthetic penicillin as a topical ocular therapy.

Abstract

BL-P1654 is a new semisynthetic penicillin that possesses broad spectrum antimicrobial activity against many gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa. An in vitro profile of BL-P1654 was established against strains of Staphylococcus aureus, Streptococcus pneumoniae, and Pseudomonas aeruginosa, three bacteria frequently associated with infections of the eye. The effectiveness of BL-P1654 in preventing the development of experimentally-induced keratitis by each of these bacteria was determined. The results of these experiments show BL-P1654 to be more effective than gentamicin and support further evaluation of the semisynthetic penicillin for ophthalmic indications.

• Authors: G D Cagle, B A Schlech
• Journal: Cornea (Cornea) Vol. 3 Issue 1 Pg. 27-32 ( 1984) ISSN: 0277-3740 [Print] United States
• PMID: 6100241 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Gentamicins
• BLP 1654
• Penicillanic Acid

Topics

• Animals
• Anti-Bacterial Agents (therapeutic use)
• Bacteria (drug effects)
• Drug Evaluation, Preclinical
• Female
• Gentamicins (pharmacology, therapeutic use)
• Keratitis (prevention & control)
• Male
• Penicillanic Acid (pharmacology, therapeutic use)
• Pseudomonas aeruginosa (drug effects)
• Rabbits
• Staphylococcus aureus (drug effects)
• Streptococcus pneumoniae (drug effects)