Efficacy of ACTH 4-9 analog, methylphenidate, and placebo on attention deficit disorder with hyperkinesis.

Abstract

The present study compared the efficacy of ACTH 4-9 analog, methylphenidate, and placebo on attention deficit disorder with 30 (HK) children with attention deficit disorder and psychometric measurements. HK children were randomly placed into three groups, according to body weight, and treated with placebo, methylphenidate, and adrenocorticotropic hormone fractions (ACTH 4-9 analog). The results revealed that HK children on methylphenidate manifested a significantly greater vasomotor reactivity, behavioral improvement, and learning receptivity than HK children taking ACTH 4-9 analog and/or placebo. Future research implications with ACTH 4-9 and HK children are discussed.

• Authors: H J Butter, Y Lapierre, P Firestone, A Blank
• Journal: Progress in neuro-psychopharmacology & biological psychiatry (Prog Neuropsychopharmacol Biol Psychiatry) Vol. 8 Issue 4-6 Pg. 661-4 ( 1984) ISSN: 0278-5846 [Print] England
• PMID: 6099589 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Peptide Fragments
• Methylphenidate
• ACTH (4-9)
• Adrenocorticotropic Hormone

Topics

• Adrenocorticotropic Hormone (therapeutic use)
• Attention Deficit Disorder with Hyperactivity (drug therapy)
• Child
• Double-Blind Method
• Humans
• Male
• Methylphenidate (therapeutic use)
• Peptide Fragments (therapeutic use)
• Random Allocation