[Study of optimal posology of penicillamine in the treatment of common rheumatoid polyarthritis (apropos of a personal series of 200 cases)].

Abstract

A comparison of two series of patients with rhe,matic polyarthritis, the one (n = 140) treated with dosage equal to or higher than 900 mg, the other (n = 60) with dosage between 600 and 750 mg, did not reveal significant difference in clinical and biological efficacy. The number of side-effects was not significantly reduced by lower dosage, except for digestive tract disorders. A reduction of dosage does, therefore, not permit less strict supervision and monitoring for side-effects of treatment.

• Authors: J P Camus, J Crouzet, A Prier, A P Leca
• Journal: Revue du rhumatisme et des maladies osteo-articulaires (Rev Rhum Mal Osteoartic) Vol. 44 Issue 12 Pg. 721-4 (Dec 1977) ISSN: 0035-2659 [Print] France
• Vernacular Title: Recherche d'une posologie optimale de la pénicillamine dans le traitement de la polyarthrite rhumatoïde commune. A propos d'une série personnelle de 200 cas.
• PMID: 609877 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Penicillamine

Topics

• Arthritis, Rheumatoid (drug therapy)
• Female
• Humans
• Male
• Middle Aged
• Penicillamine (administration & dosage, therapeutic use)