Neuroectodermal tumor and monoclonal antibodies.

Abstract

Antibody-producing clones were obtained by hybridization of spleen cells from mice immunized with whole cultured human tumor cells and mouse myeloma cells, P3UX59AG8. The tumor cells were derived from a peripheral primitive neuroectodermal tumor. One of the antibodies produced by these clones reacts with the original cell line, SK-PN-DW, and other more differentiated neuroectodermal tumors such as neuroblastomas and melanomas. The cell line SK-PN-DW contains antigenic determinants recognized by monoclonal antibodies raised against melanoma, neuroblastoma, and human fetal brain. These data indicate that this primitive neuroectodermal tumor is derived from the neuroectoderm.

• Authors: L Helson, C Weinberger, C Helson, P Lieberman
• Journal: The American journal of pediatric hematology/oncology (Am J Pediatr Hematol Oncol) Vol. 6 Issue 3 Pg. 227-31 ( 1984) ISSN: 0192-8562 [Print] United States
• PMID: 6097134 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal

Topics

• Adolescent
• Animals
• Antibodies, Monoclonal (immunology)
• Cell Line
• Enzyme-Linked Immunosorbent Assay
• Humans
• Male
• Mice
• Mice, Inbred BALB C
• Neoplasms, Germ Cell and Embryonal (immunology)