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Comparison of LATS activity and TSH receptor antibody in Graves' disease.

Abstract
TSH-receptor antibody (TRAb) activity and LATS activity of Graves' sera were compared. All of 50 LATS-positive cases were TRAb positive, although only 63% of LATS-negative cases were TRAb positive. Binding of 125I-TSH to the TSH receptors was inhibited dose-dependently by LATS-immunoglobulin. However, no correlation between TRAb activity and LATS activity was observed. TRAb was positive in 2 LATS-positive cases even when the symptoms of hyperthyroidism were controlled by treatment (antithyroid or radioisotope). The positive TRAb was not changed in 4 Graves' disease patients whose LATS activity had disappeared following antithyroid treatment. These clinical studies show that TRAb is more sensitive than LATS and suggest that LATS may be one of a heterogenous population of antibodies to the TSH receptor in Graves' disease.
AuthorsY Kajita, Y Nakajima, M Ishida, Y Ura, Y Ochi, T Miyazaki, T Hachiya, H Ijichi
JournalEndocrinologia japonica (Endocrinol Jpn) Vol. 31 Issue 3 Pg. 369-74 (Jun 1984) ISSN: 0013-7219 [Print] Japan
PMID6094169 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Autoantibodies
  • Receptors, Cell Surface
  • Receptors, Thyrotropin
  • Long-Acting Thyroid Stimulator
Topics
  • Autoantibodies
  • Graves Disease (immunology, therapy)
  • Humans
  • Long-Acting Thyroid Stimulator (immunology)
  • Receptors, Cell Surface (immunology)
  • Receptors, Thyrotropin

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