Abstract |
TSH-receptor antibody (TRAb) activity and LATS activity of Graves' sera were compared. All of 50 LATS-positive cases were TRAb positive, although only 63% of LATS-negative cases were TRAb positive. Binding of 125I-TSH to the TSH receptors was inhibited dose-dependently by LATS- immunoglobulin. However, no correlation between TRAb activity and LATS activity was observed. TRAb was positive in 2 LATS-positive cases even when the symptoms of hyperthyroidism were controlled by treatment (antithyroid or radioisotope). The positive TRAb was not changed in 4 Graves' disease patients whose LATS activity had disappeared following antithyroid treatment. These clinical studies show that TRAb is more sensitive than LATS and suggest that LATS may be one of a heterogenous population of antibodies to the TSH receptor in Graves' disease.
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Authors | Y Kajita, Y Nakajima, M Ishida, Y Ura, Y Ochi, T Miyazaki, T Hachiya, H Ijichi |
Journal | Endocrinologia japonica
(Endocrinol Jpn)
Vol. 31
Issue 3
Pg. 369-74
(Jun 1984)
ISSN: 0013-7219 [Print] Japan |
PMID | 6094169
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Autoantibodies
- Receptors, Cell Surface
- Receptors, Thyrotropin
- Long-Acting Thyroid Stimulator
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Topics |
- Autoantibodies
- Graves Disease
(immunology, therapy)
- Humans
- Long-Acting Thyroid Stimulator
(immunology)
- Receptors, Cell Surface
(immunology)
- Receptors, Thyrotropin
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