The antiviral spectrum of (E)-5-(2-bromovinyl)-2'-deoxyuridine.

Abstract

The antiviral activity spectrum of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdU) is not restricted to herpes simplex virus type 1 (HSV-1) and varicella-zoster virus (VZV) but also encompasses several other herpesviruses such as suid herpesvirus type 1 (SHV-1), bovid herpesvirus type 1 (BHV-1), simian varicella virus (SVV), herpesvirus saimiri, herpesvirus platyrrhinae, and the baculovirus Trichoplusia ni multiple nuclear polyhedrosis virus. Other herpesviruses such as herpes simplex virus type 2, cytomegalovirus and Epstein-Barr virus are also inhibited by BVdU, albeit to a lesser extent than HSV-1, VZV, SHV-1, BHV-1 and SVV.

• Authors: E De Clercq
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 14 Suppl A Pg. 85-95 (Aug 1984) ISSN: 0305-7453 [Print] England
• PMID: 6092320 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antiviral Agents
• brivudine
• Bromodeoxyuridine

Topics

• Antiviral Agents (pharmacology)
• Bromodeoxyuridine (analogs & derivatives, pharmacology)
• Cytomegalovirus (drug effects)
• DNA Viruses (drug effects)
• Herpesvirus 1, Bovine (drug effects)
• Herpesvirus 1, Equid (drug effects)
• Herpesvirus 1, Suid (drug effects)
• Herpesvirus 2, Saimiriine (drug effects)
• Herpesvirus 3, Human (drug effects)
• Herpesvirus 4, Human (drug effects)
• Insect Viruses (drug effects)
• Simplexvirus (drug effects)