Effect of 6-aminonicotinamide on monoamine oxidase and Na+K+ATPase activity in different regions of rat brain.

The monoamine oxidase activity in the cerebral hemispheres decreased significantly after 2, 4, 8 and 16 hr of 6-amino-nicotinamide (35 mg/kg body weight, i.p.) administration. In the cerebellum, the MAO activity was not affected significantly. In the brain stem, however, a significant increase was observed after 2 hr of drug administration followed by a gradual decrease at later time intervals. The Na+K+ATPase activity in the cerebral hemispheres was increased significantly at 2 and 4 hr of 6-aminonicotinamide administration. This was followed by a gradual decrease at later time intervals. In the cerebellum, like monoamine oxidase, the Na+K+ATPase did not change significantly. The brain stem showed a decrease at 2 hr of drug administration, followed by a significant increase at 4 hr and then a gradual decrease to near control values.
AuthorsC K Mayanil, S M Kazmi, N Z Baquer
JournalBiochemical pharmacology (Biochem Pharmacol) Vol. 33 Issue 19 Pg. 3021-3 (Oct 1 1984) ISSN: 0006-2952 [Print] ENGLAND
PMID6091665 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Niacinamide
  • 6-Aminonicotinamide
  • Adenosine Triphosphate
  • Monoamine Oxidase
  • Sodium-Potassium-Exchanging ATPase
  • 6-Aminonicotinamide (pharmacology)
  • Adenosine Triphosphate (analysis)
  • Animals
  • Brain (drug effects, enzymology)
  • Monoamine Oxidase (analysis)
  • Niacinamide (analogs & derivatives)
  • Rats
  • Rats, Inbred Strains
  • Sodium-Potassium-Exchanging ATPase (analysis)

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