Effect of 6-aminonicotinamide on monoamine oxidase and Na+K+ATPase activity in different regions of rat brain.

Abstract

The monoamine oxidase activity in the cerebral hemispheres decreased significantly after 2, 4, 8 and 16 hr of 6-amino-nicotinamide (35 mg/kg body weight, i.p.) administration. In the cerebellum, the MAO activity was not affected significantly. In the brain stem, however, a significant increase was observed after 2 hr of drug administration followed by a gradual decrease at later time intervals. The Na+K+ATPase activity in the cerebral hemispheres was increased significantly at 2 and 4 hr of 6-aminonicotinamide administration. This was followed by a gradual decrease at later time intervals. In the cerebellum, like monoamine oxidase, the Na+K+ATPase did not change significantly. The brain stem showed a decrease at 2 hr of drug administration, followed by a significant increase at 4 hr and then a gradual decrease to near control values.

• Authors: C K Mayanil, S M Kazmi, N Z Baquer
• Journal: Biochemical pharmacology (Biochem Pharmacol) Vol. 33 Issue 19 Pg. 3021-3 (Oct 01 1984) ISSN: 0006-2952 [Print] England
• PMID: 6091665 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Niacinamide
• 6-Aminonicotinamide
• Adenosine Triphosphate
• Monoamine Oxidase
• Sodium-Potassium-Exchanging ATPase

Topics

• 6-Aminonicotinamide (pharmacology)
• Adenosine Triphosphate (analysis)
• Animals
• Brain (drug effects, enzymology)
• Monoamine Oxidase (analysis)
• Niacinamide (analogs & derivatives)
• Rats
• Rats, Inbred Strains
• Sodium-Potassium-Exchanging ATPase (analysis)