Tumorigenicity of a rabbit lymphoid cell line transformed by human T-cell leukemia virus.

Abstract

A rabbit lymphoid cell line transformed by human T-cell leukemia virus (HTLV) was inoculated into the peritoneal cavity of six newborn hamsters treated by antilymphocyte serum. All of them developed lethal tumors two weeks after implantation. The tumor cells were chromosomally of rabbit type, and harbored HTLV and HTLV antigens.

• Authors: I Miyoshi, I Kubonishi, S Yoshimoto, Y Ohtsuki, T Akagi
• Journal: Gan (Gan) Vol. 75 Issue 6 Pg. 482-4 (Jun 1984) ISSN: 0016-450X [Print] Japan
• PMID: 6088346 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antilymphocyte Serum

Topics

• Animals
• Animals, Newborn
• Antilymphocyte Serum (pharmacology)
• Cell Line
• Cell Transformation, Viral
• Chromosomes (ultrastructure)
• Cricetinae
• Deltaretrovirus (pathogenicity)
• Lymphocytes (microbiology)
• Neoplasm Transplantation
• Neoplasms, Experimental (etiology, genetics)
• Rabbits