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Nitrendipine in hypertension that is difficult to control.

Abstract
Fifty-five patients suffering from essential or renal hypertension who had been insufficiently treated previously with combination therapy using diuretics and beta-blockers as well as reserpine, clonidine, prazosin, captopril, or minoxidil have been included in this open study. In addition to receiving diuretics and beta-blockers alone or in combination with reserpine, clonidine, or methyldopa, the patients were given nitrendipine in a dose of 2 X 20 to 2 X 40 mg/day. A normalisation of blood pressure values was attained in 46 of the 55 patients; 18 of these patients have been treated for more than 1 year. Few side-effects were observed. Dizziness and ankle oedema each occurred once. A rash occurred in one patient, causing the withdrawal of nitrendipine. No complaints of headache and palpitations were made. It may be concluded that nitrendipine is well suited as a partner in the combination treatment of patients with essential or renal hypertension that is difficult to stabilise.
AuthorsD Höffler, K Stoepel
JournalJournal of cardiovascular pharmacology (J Cardiovasc Pharmacol) Vol. 6 Suppl 7 Pg. S1060-2 ( 1984) ISSN: 0160-2446 [Print] United States
PMID6085367 (Publication Type: Journal Article)
Chemical References
  • Adrenergic beta-Antagonists
  • Calcium Channel Blockers
  • Diuretics
  • Nitrendipine
  • Nifedipine
Topics
  • Adrenergic beta-Antagonists (therapeutic use)
  • Adult
  • Aged
  • Blood Pressure (drug effects)
  • Calcium Channel Blockers (therapeutic use)
  • Diuretics (therapeutic use)
  • Drug Therapy, Combination
  • Female
  • Humans
  • Hypertension (drug therapy)
  • Male
  • Middle Aged
  • Nifedipine (analogs & derivatives, therapeutic use)
  • Nitrendipine

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