Abstract |
Fifty-five patients suffering from essential or renal hypertension who had been insufficiently treated previously with combination therapy using diuretics and beta-blockers as well as reserpine, clonidine, prazosin, captopril, or minoxidil have been included in this open study. In addition to receiving diuretics and beta-blockers alone or in combination with reserpine, clonidine, or methyldopa, the patients were given nitrendipine in a dose of 2 X 20 to 2 X 40 mg/day. A normalisation of blood pressure values was attained in 46 of the 55 patients; 18 of these patients have been treated for more than 1 year. Few side-effects were observed. Dizziness and ankle oedema each occurred once. A rash occurred in one patient, causing the withdrawal of nitrendipine. No complaints of headache and palpitations were made. It may be concluded that nitrendipine is well suited as a partner in the combination treatment of patients with essential or renal hypertension that is difficult to stabilise.
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Authors | D Höffler, K Stoepel |
Journal | Journal of cardiovascular pharmacology
(J Cardiovasc Pharmacol)
Vol. 6 Suppl 7
Pg. S1060-2
( 1984)
ISSN: 0160-2446 [Print] United States |
PMID | 6085367
(Publication Type: Journal Article)
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Chemical References |
- Adrenergic beta-Antagonists
- Calcium Channel Blockers
- Diuretics
- Nitrendipine
- Nifedipine
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Topics |
- Adrenergic beta-Antagonists
(therapeutic use)
- Adult
- Aged
- Blood Pressure
(drug effects)
- Calcium Channel Blockers
(therapeutic use)
- Diuretics
(therapeutic use)
- Drug Therapy, Combination
- Female
- Humans
- Hypertension
(drug therapy)
- Male
- Middle Aged
- Nifedipine
(analogs & derivatives, therapeutic use)
- Nitrendipine
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